(UroToday.com) In the phase III PROfound study, olaparib lead to significantly longer radiographic progression-free survival compared with physician’s choice of next-generation hormonal agent (control) in patients with previously treated metastatic castration-resistant prostate cancer (mCRPC) and alterations in homologous recombination repair (HRR) genes.1 The study protocol allowed patients in the control arm who experienced radiographic disease progression to switch to olaparib treatment, if they also met other prespecified criteria: