(UroToday.com) The overall incidence of human papillomavirus (HPV) DNA in penile cancer is 42-70%, which is lower than cervical carcinoma (~100%), and similar to vulvar carcinoma (~50%). HPV prevalence differs by histologic subtype in penile cancer, including 100% of the ‘warty’ subtype, 80% for basaloid, 34.9% for keratinizing squamous cell carcinoma, and 33% of verrucous carcinoma. However, data related to the impact of HPV infection status and the outcome of perioperative treatments in patients with lymph node-involved penile squamous-cell carcinoma are lacking. At the virtual European Society of Medical Oncology – (ESMO) 2020 annual meeting, Dr. Andrea Necchi and colleagues reported results of their study analyzing the benefit of perioperative radiotherapy according to HPV infection status.