(UroToday.com) Penile cancer is rare with an incidence of <1 per 100,000 in Western industrialized nations. Metastatic penile squamous carcinoma is a very rare disease with poor outcomes (overall survival < 1 year) despite the use of platinum-based chemotherapy agents. There is limited real-world data on how these patients are managed in clinical practice and their outcomes. At the European Society for Medical Oncology Virtual Congress (ESMO) 2020 annual meeting, Dr. Wing Kin Liu and colleagues presented results of their institutional long-term experience with metastatic penile cancer, which is the largest review of such patients to date.