(UroToday.com) There is an urgency to develop therapies with novel mechanisms of action to treat prostate cancers resistant to chemohormonal and radiation therapies. Unfortunately, to date, immune therapies have offered limited efficacy in patients with metastatic castration-resistant prostate cancer (mCRPC). More recently, there has been excitement regarding PSMA as a clinically validated therapeutic target in prostate cancer. AMG 160 is a targeted half-life extended, bispecific T-cell engager (BiTE®) immune therapy that engages a patient’s own T cells to kill prostate cancer cells via binding of CD3 on T cells and PSMA on cancer cells: