(UroToday.com) COSMIC-021 is a clinical trial platform testing the combination of the MET/VEGF/TAM kinase inhibitor cabozantinib in combination with the anti-PD-L1 drug atezolizumab. The rationale for this combination is based on data suggesting that cabozantinib promotes an immune-permissive environment that may enhance responses to immune checkpoint blockade, and clinical data showing promising combination activity in multiple tumor types. In this presentation, Dr. Pal shared data from a cohort of COSMIC-021 (NCT03170960) examining the efficacy (by objective response rate) and safety of this drug combination in previously untreated patients with advanced clear-cell renal cell carcinoma (ccRCC).