(UroToday.com) Docetaxel is an approved therapy for the treatment of men with metastatic castration-resistant prostate cancer (mCRPC) that may work in part by inducing immunogenic cell death of prostate cancer cells. The KEYNOTE-365 study (NCT02861573) tested this hypothesis in its cohort B arm with a study of standard dosing pembrolizumab and docetaxel with prednisone 5 mg daily. Initial results from this cohort were presented at ASCO 2019, showing an objective response rate in patients with RECIST-measurable disease of 14%, disease control rate of 50%, and median progression-free survival of 8 months. In this presentation, Dr. Emanuela Romano and colleagues present updated results after additional enrollment and longer follow-up.