Our study aimed at identifying prognostically relevant genes as plausible targets for further research by using the comprehensive The Cancer Genome Atlas (TCGA) datasets.2 By performing systematic survival analyses across 30 different tumor entities, we discovered the so far widely unknown gene Downstream neighbor of SON (DONSON) gene to be a particularly strong predictor of unfavorable overall survival (OS) in different tumor entities, suggesting DONSON to possess tumor-independent oncogenic properties.