(UroToday.com) Dr. Peter Pinto began this session with an update on the comparison between MRI targeted vs. systematic prostate biopsy. The systematic prostate biopsy has a low sensitivity and specificity in detecting clinically significant prostate cancer (PCa). It may only sample 0.04% of the gland,1 and it has difficulty in sampling the anterior and apical regions.2 It is also less effective in patients with prior negative biopsy.3