If a therapy in castrate-resistant prostate cancer (CRPC) shows an improvement in progression-free survival, but not overall survival, should that change practice? The topic is top of mind for us this month based on the results of the ACIS study presented at the ASCO GU 2021 Genitourinary Cancers Symposium by Dana Rathkopf of Memorial Sloan Kettering – and I’ll explore it here. To briefly recap, ACIS compared abiraterone to abiraterone plus apalutamide in men with chemotherapy naïve CRPC.