As in politics and history, in drug development, enthusiasm for a concept swings back and forth like a pendulum. Oftentimes when a therapy is new and fresh it is met with responses like “will we simply stop using all other therapies? Is this the one treatment that is going to make future clinical trials unnecessary?” It becomes all about the new thing. The current approaches that have entered this stage are the parp inhibitors (Parpi) and soon, I predict radioligand therapy.