(UroToday.com) The joint session of the European Association of Urology (EAU) and the Canadian Urological Association at the 2021 EAU annual meeting included a discussion on PSA, Imaging and Beyond for assessing men for prostate biopsy and a presentation by Dr. Nicolas Mottet about keeping the process simple. Dr. Mottet notes that an indication for biopsy should be reserved for when a diagnosis is needed, in an asymptomatic man with an abnormal DRE or elevated PSA, and occasionally in symptomatic men (if the symptoms are possibly related to prostate cancer). For men with an abnormal DRE when the PSA is <2 ng/ml the positive predictive value for a positive biopsy is up to 30%. For men with an elevated PSA, it is not specific if limited to one lab value and must be rechecked (in the same lab) after several weeks to standardize conditions.