(UroToday.com) The 2021 American Urological Association (AUA) Summer School series included a session on the Evaluation and Management of Adrenal Masses moderated by Dr. Neal E. Rowe, and a presentation from Dr. Rowe discussing the management of functional adrenal tumors, specifically hypercortisolism. Hypercortisolism is Cushing’s Syndrome, which is defined as the prolonged and inappropriate exposure to excessive glucocorticoids. Excess cortisol can be due to increased ACTH secretion (ACTH-dependent, 85% of cases), independent adrenal overproduction (ACTH-independent, 10% of cases), or exogenous corticosteroids. Production of cortisol is intimately associated with the hypothalamic-pituitary-adrenal axis: