(UroToday.com) The 2021 American Urological Association (AUA) Summer School series included a session on the Evaluation and Management of Adrenal Masses moderated by Dr. Neal E. Rowe, and a presentation from Dr. Rowe discussing the management of functional adrenal tumors, specifically primary aldosteronism. Dr. Rowe notes that primary aldosteronism is also called Conn’s Syndrome, highlighted by inappropriately high aldosterone production, which is not suppressed by sodium loading. This clinical scenario results in hypertension, cardiovascular damage, and hypokalemia. The most common causes of Conn’s Syndrome include bilateral adrenal hyperplasia (60% of cases), adrenal adenoma (35% of cases), and unilateral hyperplasia (2% of cases). Rare causes are secondary to ovarian aldosterone-producing tumors, adrenocortical carcinoma, and familial hyperaldosteronism. Conn’s Syndrome is connected to the renin-angiotensin-aldosterone system, as highlighted in the following figure: