(UroToday.com) The European Society of Medical Oncology (ESMO) 2021 annual meeting’s prostate cancer session included a presentation by Dr. Bertrand Tombal discussing a subgroup analysis of the phase 3 HERO study assessing the efficacy and safety of relugolix versus leuprolide among men with advanced prostate cancer. Androgen deprivation therapy is a cornerstone of prostate cancer treatment and is usually given with gonadotropic-releasing hormone (GnRH) agonists or GnRH receptor antagonists. Relugolix, the once-daily oral GnRH receptor antagonist, demonstrated suppression of testosterone to castrate levels in 96.7% of patients, and a 54% lower risk of major adverse cardiovascular events relative to leuprolide in the HERO study.1 At the ESMO 2021 meeting, Dr. Tombal and colleagues presented the results of a subgroup analysis undertaken to further evaluate relugolix treatment for various clinical subgroups included in the HERO study.