(UroToday.com) The Société Internationale D’Urologie (SIU) 2021 annual meeting included a master class on advanced kidney cancer with a presentation by Dr. Kevin Lu discussing nephrectomy as part of the sequencing options in metastatic renal cell carcinoma (RCC) with the primary in place. Dr. Lu notes that we are in a rapidly evolving treatment landscape for metastatic RCC, highlighted by new drugs, drug combinations, drug sequences, vaccinations, improving local management, and precision therapy. As follows is a timeline of the current therapeutics available for advanced RCC: