Squamous cell carcinoma of the urinary bladder associated with non-schistosomiasis (NSR-SCCUB) is an uncommon tumor subtype distinct from urothelial carcinoma (UC). NSR-SCCUB type is slightly more prevalent in men and is associated with chronic bladder irritation from chemotherapy, chronic bladder infections, or indwelling catheters. In addition, patients with these tumors tend to have a higher T stage at diagnosis (T2). Anatomically, the bladder’s trigone and lateral walls are commonly affected.