Pegilodecakin as monotherapy or in combination with anti-PD-1 or tyrosine kinase inhibitor in heavily pretreated patients with advanced renal cell carcinoma (RCC): Final results of cohorts A, G, H, and I of IVY Phase I study.

Interleukin (IL)-10 has anti-inflammatory and CD8+ T-cell-stimulating properties. Pegilodecakin (pegylated recombinant human IL-10) induces intra-tumoral antigen specific CD8+T-cells and upregulates IFNγ and Major Histocompatibility Complex (MHC) I and II.