Many articles about prostatitis start with obligatory language saying how “not much is known” about the etiology and treatment is frustrating. Perhaps that’s true if every man with pain between his nipples and knees is given antibiotics until they improve or go to the next doctor. Following the simple syndrome-based NIH classification system and evidence-based therapies leads to successful outcomes in the majority of patients. Part of the confusion is that there are 4 distinct syndromes with little in common that are all given the name Prostatitis.