(UroToday.com) The treatment landscape in the first-line therapy of metastatic renal cell carcinoma (mRCC) has rapidly evolved over the past 3 years. Each of these treatment approaches has utilized an immunotherapy backbone with immune checkpoint inhibition. In a presentation at the European International Kidney Cancer 2021 Virtual Annual Meeting, Dr. Sautes-Fridman discussed the potential for targeting of the tumor microenvironment.