(UroToday.com) Prostate cancer remains the most commonly diagnosed malignancy for men in the United States. Genetic inheritance does portend significant risk in developing aggressive prostate cancer, yet there is limited understanding of whether germline alterations play a significant role in localized disease for men on active surveillance. At the Southeastern Section of the AUA 2021 virtual meeting, fourth-year medical student Scott Brimley and colleagues presented results of their study assessing whether germline screening in patients presenting for active surveillance with low risk prostate cancer could provide prognostic information regarding risk of pathologic upgrading or disease progression.