(UroToday.com) Advanced germ cell tumors (GCT) are one of the true success stories of modern oncology in which we can reasonably consider a cure for patients with advanced disease. However, patients may experience late relapse, defined as relapsed disease > 2 years from initial treatment. Such late relapse remains a challenge both in terms of identification and treatment: optimal screening approaches are not settled and treatment approaches include both surgery and chemotherapy.