A Randomized Phase II Study of 177 LuPSMA-617 vs Docetaxel in Patients With Metastatic Castration-Resistant Prostate Cancer and PSMA-Positive Disease

Condition: Prostate Cancer

Study Type: Interventional

Clinical Trials Identifier NCT 8-digits: NCT04663997

Sponsor: Canadian Cancer Trials Group

Phase: Phase 2

Eligibility:

Inclusion Criteria:

Histological evidence of prostate cancer with no evidence of small cell component
Patients must have castration resistance and metastatic disease with evidence of biochemical or imaging progression in the setting of surgical/medical castration
Progression on treatment with abiraterone and/or enzalutamide, or similar next-generation androgen receptor (AR) targeted therapy
Evidence of PSMA positive metastatic disease, as assessed on PSMA-PET imaging studies obtained as part of other clinical trial protocols are mandated, provided they are obtained within a timeframe that meets the requirements of this study. The radiopharmaceuticals must be based on a lysine-urea-glutamate backbone, with a 18F or 68Ga radionuclide label.
Prior orchiectomy, or if on LHRH agonist/antagonist then testosterone < 1.7 nmol/L
Adequate organ function
Recover from all previous cancer treatment toxicities to grade ≤ 2 (as per CTCAE v5.0)
Male subject ≥ 18 years of age
Eastern Cooperative Oncology Group (ECOG) performance status 0-2

Exclusion Criteria:

Prior treatment with chemotherapy for castration-resistant disease or prior docetaxel in the castration sensitive (hormone-sensitive) setting ≤ 1 year prior to enrollment.
Prior treatment with 177Lu-PSMA (including other radiolabeled therapeutic PSMA-ligands) or radio-immunotherapy
Radiotherapy to target lesions (measurable disease) ≤ 12 weeks prior to enrolment
Presence of majority (> 50% of lesions) or large (> 5 cm) soft tissue lesions that are negative on PSMA-Ligand PET/CT or PSMA-Ligand PET/MR
Known parenchymal brain metastases
Active epidural disease (treated epidural disease is permitted)
Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial.
Clinically significant cardiac disease
Major surgery within 4 weeks of starting study treatment