(UroToday.com) The 2021 American Urological Association (AUA) Summer School session on Upper Tract Urothelial Carcinoma included a case-based discussion led by moderator Dr. Surena Matin who was joined by panelists Dr. Sima Porten and Dr. Vitaly Margulis. Upper tract urothelial carcinoma accounts for 5-10% of all urothelial cancers, with an incidence of 2 per 100,000 people in Western countries. Concurrent disease with bladder cancer occurs in 17% of patients, with recurrence in the bladder among 22-47% of individuals. Furthermore, upper tract urothelial carcinoma develops in 2-4% of patients with a history of bladder cancer, and 60% of upper tract urothelial carcinoma cases are invasive at diagnosis.