(UroToday.com) The 2021 American Urological Association (AUA) Summer School session on Upper Tract Urothelial Carcinoma included a case-based discussion led by moderator Dr. Surena Matin who was joined by panelists Dr. Sima Porten and Dr. Vitaly Margulis. This case highlighted high-risk upper tract urothelial carcinoma in a solitary kidney with synchronous bladder urothelial carcinoma. The patient was a 58-year-old female with Lynch Syndrome and a surgical history consistent with a hysterectomy 10 years ago for endometrial cancer. Additionally, she had a right nephroureterectomy in 2005 (unknown stage and grade of tumor), with new recurrence bladder CIS after BCG induction (no maintenance given), with a new left high-grade upper tract urothelial carcinoma at the ureteropelvic junction (cTx-1), as well as mid and distal ureteral tumors: