(UroToday.com) Upper tract urothelial carcinoma (UTUC) is a relatively rare malignancy, comprising a small subset of urothelial disease. The diagnosis of UTUC is often delayed as a result of vague, non-specific, or absent symptoms until significant disease progression. Further, compared to bladder cancer, endoscopic diagnosis, and management of UTUC is substantially more difficult which makes diagnosis and preoperative risk stratification more difficult.