(UroToday.com) In this analysis by Andrew Salib and colleagues, the authors explore on a larger scale the risk of developing secondary malignancies after pelvic radiation therapy for a primary pelvic malignancy (rectal/anal, bladder, prostate, uterine, cervical). While confirming that radiation treatment for pelvic malignancies increases the risk of developing secondary malignancies over the patient’s lifetime, the risk is different depending on the primary tumor histology.