To study the effect of three antioxidants viz. selenium, carnitine and coenzyme Q10, alone or in combination, on both semen parameters and pregnancy rates in couples with male factor infertility.

Using PRISMA guidelines, a systematic search was performed of the PubMed®, Scopus®, EMBASE®, and Web of Science® databases for randomized studies comparing selenium, carnitine or coenzyme Q10 with placebo in the treatment of male infertility and reporting semen and pregnancy outcomes.

X