(UroToday.com) The novel micro-ultrasound system operating at 29 MHz operates at a higher level than the conventional 6-9 MHz systems. This results in 300% improvement in resolution, both axial and laterally down to 70 microns, allowing visibility of suspicious areas using the prostate risk identification using a micro-ultrasound (PRI-MUS) system.1 Micro-ultrasound may be used to image suspicious lesions and target biopsies in real-time with or without additional MRI-based targets. This approach offers the benefits of simplicity, a single intervention for imaging and biopsy, leveraging the low cost of ultrasound. At the American Urological Association (AUA) 2020 virtual annual meeting, Dr. Giovanni Lughezzani and colleagues presented results of their study comparing the sensitivity, specificity, negative predictive value, and positive predictive value of mpMRI with the novel high-resolution micro-ultrasound imaging modality.