Clear cell renal cell carcinoma (ccRCC), the most common subtype of renal cancer, has a poor clinical outcome. A hallmark of ccRCC is genetic loss-of-function of Von-Hippel Lindau (VHL) that leads to a highly vascularized tumor microenvironment.
Clear cell renal cell carcinoma (ccRCC), the most common subtype of renal cancer, has a poor clinical outcome. A hallmark of ccRCC is genetic loss-of-function of Von-Hippel Lindau (VHL) that leads to a highly vascularized tumor microenvironment.