Baseline levels of seminal reactive oxygen species predict improvements in sperm function following anti-oxidant therapy in men with infertility.

Poor sperm function is a major cause of infertility. There is no drug therapy to improve sperm function. Semen oxidative stress is a recently identified pathway for sperm damage. Commercial anti-oxidants such as L-carnitine and acetyl-L-carnitine (LAL) are commonly self-administered by infertile men.