(UroToday.com) Non-clear cell renal carcinomas comprised approximately 25% of all renal cell carcinomas (RCC), and are notable for heterogeneous histologies, limited treatment options and worse outcomes relative to clear-cell RCC. Cabozantinib is a tyrosine kinase inhibitor (TKI) that impacts the TAM kinases (TYRO3, AXL, MER), VEGFR2, and MET, with the cumulative effects shown in the figure below.