ESMO Virtual Congress 2020: PROREPAIR-A Study Results: Clinical Impact of Somatic Alterations in Prostate Cancer Patients with and without Previously Known Germline BRCA1/2 Mutations

(UroToday.com) Germline mutations in BRCA2 (gBRCA2) are associated with prostate cancers that are more aggressive and have poorer clinical outcomes relative to other prostate cancers. These tumors are associated with more genomic copy number alterations including loss of BRCA2, RB1, and amplification of MYC.