(UroToday.com) APOBEC-driven mutagenesis and functional positive selection of mutated genes may synergistically drive the higher frequency of some hotspot driver mutations within the same gene in bladder cancer. However, only a few APOBEC-associated driver hotspot mutations have been identified in bladder cancer. Dr. Shi and colleagues from Institut Curie, Paris, present an effort to systematically look for and characterize APOBEC-associated hotspots in bladder cancer.