Catheter-associated urinary tract infections (CAUTIs) are a major cause of harm in hospitalized children. While CAUTI prevention insertion and maintenance bundles have been developed, implemented, and validated in adult populations, their applicability to pediatric populations has been unclear because validation studies in children have been limited to small populations with a short duration of follow up. Our report in Pediatrics describes the CAUTI prevention efforts of the Children’s Hospitals’ Solution for Patient Safety (SPS), a pediatric safety engagement network consisting of over 135 children’s hospitals.1,2