(UroToday.com) During the Best of Bladder Cancer session during the 2020 Society of Urologic Oncology (SUO) annual meeting, Dr. Andrew Lenis presented on his group’s experience with genomic characterization of cystectomy patients. Currently, the standard of care for muscle-invasive bladder cancer is neoadjuvant chemotherapy followed by radical cystectomy. The majority of studies in this space have focused on chemotherapy treatment-naïve patients with the aim of preoperative risk stratification and treatment selection. However, current trials are investigating the role of adjuvant immunotherapy in patients with the chemo-resistant disease. For this reason, the group at Memorial Sloan Kettering Cancer Center (MSKCC) sought to elucidate the molecular biology of chemo-resistant disease in order to help expand therapeutic options.