Socioeconomic Status-Related Parameters as Predictors of Competing (Non-Bladder Cancer) Mortality after Radical Cystectomy.

To investigate the impact of socioeconomic status-related parameters on competing (non-bladder cancer) mortality after radical cystectomy. A total of 1,268 consecutive patients who underwent radical cystectomy for urothelial or undifferentiated bladder cancer at our institution between 1993 and 2016 with a mean age of 69 years (median 70 years) were studied. The mean -follow-up of […]

Analyses of FGFR3 and PIK3CA mutations in neuroblastomas and the effects of the corresponding inhibitors on neuroblastoma cell lines.

Fibroblast growth factor receptor (FGFR)3 and phosphatidylinositol‑4,5‑bisphosphate 3‑kinase, catalytic subunit alpha (PIK3CA) mutations are found in various types of cancer, such as urinary bladder cancer, human papillomavirus‑positive tonsillar and base of the tongue squamous cell carcinoma, breast cancer and some childhood sarcomas. Several drugs can target these genes, some of which have been used for […]

Robot Assisted Radical Cystectomy vs Open Radical Cystectomy: Over 10 years of the Mayo Clinic Experience – Beyond the Abstract

Radical cystectomy (RC) is the standard treatment for optimal survival and oncological outcomes for patients with invasive bladder cancer requiring definitive treatment. The use of robot assisted radical cystectomy (RARC) for bladder cancer has increased significantly in recent years. Our institution is a high-volume cystectomy center with surgeons that perform both RARC and open radical […]

Robot Assisted Radical Cystectomy vs Open Radical Cystectomy: Over 10 years of the Mayo Clinic Experience – Beyond the Abstract

Radical cystectomy (RC) is the standard treatment for optimal survival and oncological outcomes for patients with invasive bladder cancer requiring definitive treatment. The use of robot assisted radical cystectomy (RARC) for bladder cancer has increased significantly in recent years. Our institution is a high-volume cystectomy center with surgeons that perform both RARC and open radical […]

ACS 2019: Is Cystoscopy a Major Source of Discomfort and Anxiety for Bladder Cancer Patients?

San Francisco, California (UroToday.com) Dr. Mark Ehlers reviewed how bladder cancer is a common cancer leading to >1,000,000 cystoscopies in the US yearly. Anxiety and discomfort have a significant impact on diagnosis and treatment. Their objective was to evaluate the degree of anxiety and discomfort associated with bladder cancer patients’ most recent cystoscopy and alleviating […]

ACS 2019: The Harms of Hematuria Workup: Modeling the Risk-Benefit of Using Split-Bolus CT Urography to Reduce Radiation Exposure in a Theoretical Cohort

San Francisco, California (UroToday.com) Jeremiah Dallmer discussed how CT urography (CTU) is used to evaluate patients with gross (GH) or microscopic hematuria (MH). CTU is a high radiation dose scan and thus confers a higher risk of secondary malignancy. A CTU “Split-Bolus” (SB) protocol reduces radiation exposure; however, it may reduce sensitivity.   This study uses a […]

ACS 2019: Peri-Operative Outcomes and Discharge Destinations of Octogenarians Undergoing Radical Cystectomy: An Analysis of the NSQIP Database

San Francisco, California (UroToday.com) Dr. Hayden M. Hill presented work regarding radical cystectomy in the elderly and corresponding outcomes. Due to an aging general population, patients older than 80 years of age with muscle-invasive bladder cancer (MIBC) will increasingly undergo a radical cystectomy (RC). Discharge destination for elderly patients has been shown to be predictive […]

ACS 2019: Does Sarcopenia Predict Poor Outcomes Following Radical Cystectomy? A Contemporary Analysis and Evaluation of Commonly Used Criteria

San Francisco, California (UroToday.com) Nicholas B. Drury discussed how inconsistent cutoff values to define sarcopenia have been utilized throughout the literature. Their aim was to evaluate sarcopenia as a predictor of perioperative outcomes and survival following radical cystectomy with urinary diversion (RCUD) using the international consensus definition, Martin criteria, and Mayr criteria, as a standardized […]

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