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LCI-GU-URO-CRI-001: A Phase II Study of Crizotinib in Patients With c-MET or RON-Positive Metastatic Urothelial Cancer Condition: Urinary Bladder Neoplasms, Ureteral Neoplasms, Urethral Neoplasms Intervention: Drug: Crizotinib Purpose: This is a single arm two-stage phase II study with crizotinib (Xalkori®) in the treatment of subjects with metastatic urothelial cancer of the bladder, upper (ureter or […]

Pilot Study of Pencil Beam Scanning Proton Beam Radiation Therapy in Patients With Renal Tumors Condition: Renal Tumor, Wilms Tumor Intervention: Other: Proton beam radiation using pencil beam scanning Purpose: This is a pilot study to assess acute toxicity in patients receiving flank irradiation using proton therapy for renal tumors. Study Type: Interventional Clinical Trials […]

Pilot Study to Evaluate the Biologic Effect of CBM588 in Combination With Nivolumab/Ipilimumab for Patients With Metastatic Renal Cell Carcinoma Condition: Advanced Renal Cell Carcinoma, Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8, Unresectable Renal Cell Carcinoma Intervention: Drug: Clostridium […]

Investigating a Novel Modifiable Factor Affecting Renal Function After Partial Nephrectomy: Cortical Renorrhaphy Condition: Renal Cell Carcinoma Intervention: Procedure: Non-renorrhaphy Procedure: Renorrhaphy Purpose: Preserving kidney function during removal of a kidney tumor is becoming increasingly important as rates of chronic kidney disease increase. A novel modifiable factor (suture closure of the defect caused by tumor […]

A Randomized Phase II Trial of Stereotactic Body Radiation Therapy (SBRT) With or Without Durvalumab (MEDI4736) in Oligometastatic Recurrent Hormone Sensitive Prostate Cancer Patients Condition: Node; Prostate, Bone Metastases, Prostate Cancer Patients Intervention: Combination Product: SBRT + Durvalumab Radiation: SBRT Purpose: As in other solid tumours, increasing evidence indicates that patients diagnosed with a limited […]

Athens, Greece (UroToday.com) In this debate, Dr. R. Jeffrey Karnes explained why he believes in the role of radical prostatectomy in the management of oligometastatic prostate cancer. There are many reasons why it is important to control the primary tumor in oligometastatic disease according to Dr. Karnes: Diminish symptoms that are caused by the primary tumor […]