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The impact of resection technique on partial nephrectomy (PN) outcomes is controversial. The aim of the study is to evaluate the pattern of resection techniques during PN and their impact on perioperative outcomes, acute kidney injury (AKI), positive surgical margins (PSM) and Trifecta achievement. Data from consecutive patients with cT1-2N0M0 renal masses treated with PN […]

Whole pelvis radiotherapy (WPRT) may improve clinical outcomes over prostate-only radiotherapy (PORT)in high-risk prostate cancer patients by sterilization of micrometastatic nodal disease provided there is optimal control of the primary site. A prospective multicentre cohort study of eligible patients (stage ≥T2c, Gleason score ≥7 or presenting prostate-specific antigen (pPSA) ≥10) treated between 2009 and 2013 […]

Multiparametric magnetic resonance imaging (mpMRI) with informed targeted biopsies (TGBX) has changed the paradigm of prostate cancer (PCa) diagnosis. Randomized studies have demonstrated a diagnostic benefit of Clinically significant (CS) for TGBX compared to standard systematic biopsies (SBX). We aimed to evaluate whether mpMRI-informed TGBX has superior diagnosis rates of any-, CS-, high-grade (HG)-, and […]

Background: Despite the increasing worldwide utilization of stereotactic body radiation therapy (SBRT) for prostate cancer, there are no known summative data regarding its safety and efficacy. To address this knowledge gap, we conducted a PRISMA-guided systematic review and meta-analysis of prospective prostate SBRT trials. Results: Fourteen trials with a total of 2,038 patients were included. […]

To compare the clinical validity and utility of Likert assessment and the Prostate Imaging Reporting and Data System (PI-RADS) v2 in the detection of clinically significant and insignificant prostate cancer. 489 pre-biopsy multiparametric MRI (mpMRI) scans in consecutive patients underwent prospective paired reporting using both Likert and PI-RADS v2 by expert uro-radiologists. Patients were offered […]

The oncological benefit of pelvic lymph node dissection (PLND) is still debatable because data on clinical outcomes of radical prostatectomy (RP) without PLND are lacking. In this study, we reported oncological outcome in consecutive 146 patients who underwent RP without PLND. Although 27% of our patients developed biochemical recurrence, the estimated 5-year overall survival rates […]

Sia Daneshmand: Hi everyone. My name is Sia Daneshmand. I’m the Director of Urologic Oncology at USC, University of Southern California in Los Angeles, and from the Norris Comprehensive Cancer Center. And today we’re going to talk about this article on “Evaluation of Cxbladder, and Adjudication of Atypical Cytology and Equivocal Cystoscopy”. You see there […]

The oncogene addiction model occurs when cancer cells become dependent on one mutated oncogene or pathway for the maintenance of a malignant phenotype. Withdrawal of the oncogenic signal leads to the regression of cancer. The role of oncogenic addiction in precursor lesions such as hyperplasia is not well understood. A recent study by Yee et […]

Alicia Morgans: Hi, this is Alicia Morgans. I’m a Medical Oncologist, a GU Medical Oncologist at Northwestern University. I am so excited today to have my colleague and friend, Dr. Maha Hussain, on the line to share with us some information about the PROfound study. Dr. Hussain is a Professor of Medicine and the Deputy […]

To predict survival outcomes for individual patients with clinical T1 high-grade (T1HG) bladder cancer (BC), data from the Surveillance Epidemiology and End Results (SEER) database were analyzed in the present study. The data of 6,980 cases of T1HG BC between 2004 and 2014 were obtained from the SEER database. Uni- and multivariate Cox analyses were […]