Latest News

Aarhus, Denmark (UroToday.com) Margaret Knowles presented the International Bladder Cancer Network (IBCN) Keynote address regarding the clinical application of molecular features of non-muscle invasive bladder cancer (NMIBC). She reviewed her work in NMIBC and specifically mutation analysis, exome sequencing, transcriptome, and genome wide NGS to determine copy number. A major question with NMIBC is should we […]

Aarhus, Denmark (UroToday.com) Richard Hautmann, from the University of Ulm, Ulm Germany, presented the International Bladder Cancer Network (IBCN) Keynote address regarding the evolution of surgical innovation in bladder cancer care. Dr. Hautmann is Chairman emeritus University of Ulm who’s published over 500 papers and book chapters specific to bladder cancer. He presented the history of […]

Bladder cancer (BCa) is a tumor associated with high morbidity and mortality and its incidence is increasing worldwide. However, the pathogenesis of bladder cancer is not well understood. To further illustrate the molecular mechanisms involved in the pathogenesis of BCa and identify potential therapeutic targets, we combined the transcriptomic analysis with RNA sequencing and tandem […]

To evaluate role of Multiparametric MRI in differentiation between invasive and non-invasive bladder cancer and accuracy of vesical imaging reporting and data system (VI-RADS) score. Fifty patients diagnosed as cancer bladder were enrolled in this study, mp-MRI including conventional (T1WI and high resolution T2WI) and functional sequences (Diffusion WI and DCE-MRI) were done, all data […]

To investigate the correlations of the expression of micro ribonucleic acid (miR)-203 with the onset and prognosis of bladder cancer. Human bladder cancer T24 cell line with miR-203 overexpression were constructed. Effects of miR-203 expression on cell proliferation and apoptosis were detected via methyl thiazolyl tetrazolium (MTT) assay and flow cytometry, respectively. Fifty-eight patients with […]

Among renal cell carcinoma (RCC) the tumor immune microenvironment has been best characterized in clear cell RCC. In this study we investigated the expression of several immune markers including PD-L1, FOXP3, and CD8 in primary and metastatic papillary RCC. Three tissue microarrays were constructed from 78 cases with primary papillary RCC and paired metastatic tumor […]

Clear cell renal cell carcinoma (ccRCC) is one of the most common malignant tumors in the urinary system. Surgical intervention is the preferred treatment for ccRCC, but targeted biological therapy is required for postoperative recurrent or metastatic ccRCC. Autophagy is an intracellular degradation system for misfolded/aggregated proteins and dysfunctional organelles. Defective autophagy is associated with […]

Screening for renal cell carcinoma (RCC) has been identified as a key research priority; however, no randomised control trials have been performed. Value of information analysis can determine whether further research on this topic is of value. To determine (1) whether current evidence suggests that screening is potentially cost effective and, if so, (2) in […]

The purpose of the present study was to validate the new GRade, Age, Nodes and Tumor (GRANT) score for renal cell carcinoma (RCC) prognostication within a large population of patients. Within the Surveillance, Epidemiology, and End Results database, we identified patients with either clear-cell or papillary RCC, who underwent nephrectomy between 2001 and 2015. Harrell’s […]