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To assess the prognostic and diagnostic utility of PSA immunostaining, tissue microarrays containing 17,747 prostate cancers, 3,442 other tumors from 82 different (sub) types and 608 normal tissues were analyzed at two different antibody concentrations (1:100 and 1:800). In normal tissues, PSA expression was limited to prostate epithelial cells. In prostate cancers, PSA staining was […]

The aim of this study was to evaluate the detection rate of [68Ga]prostate-specific membrane antigen ([68Ga]PSMA-11) positron emission tomography (PET)/magnetic resonance imaging (MRI) and to compare it with [68Ga]PSMA-11 PET/X-ray computed tomography (CT) in patients with recurrent prostate cancer (PC) after radical prostatectomy. A total of 93 patients with biochemically recurrent prostate cancer underwent [68Ga]PSMA-11 […]

We evaluated prognostic risk factors of recurrence-free survival (RFS), metastasis-free survival (MFS), cancer-specific survival (CSS), and overall survival (OS) outcomes in patients with non-metastatic renal cell carcinoma (nmRCC) after curative nephrectomy during long-term follow-up. The medical records of 4,260 patients with nmRCC who underwent curative nephrectomy between 2000 and 2012 from five Korean institutions and […]

Nivolumab has been introduced for metastatic renal cell carcinoma (mRCC) as a second-line therapy for years. However, despite widespread evidence of its utility, few reports have described the efficacy of nivolumab for mRCC patients on hemodialysis. A 68-year-old man with a 20-year history of dialysis due to chronic glomerulotubular nephritis was referred to our department […]

Background and objectives: In patients with metastatic renal cell cancer (mRCC), cytoreductive nephrectomy (CN) may occasionally be performed. However, the role of lymph node dissection (LND) for such cases is unknown in era of target therapy. To test the effect of LND at CN on cancer-specific survival (CSS), overall survival (OS) in era of target […]

Testicular germ cell tumors (TGCTs) are an excellent example of chemosensitive disease. However, cisplatin-based chemotherapy has significant side effects, including myelosuppression. Previously, we found endogenous DNA damage level in peripheral blood mononuclear cells (PBMCs) to be an independent prognostic marker. In this study, we tested the hypothesis that patients with high endogenous DNA damage levels […]

Imaging of the Prostate Gland Using High Field Strength 3T MRI Condition: Prostate Cancer Intervention: Procedure: 3-Tesla magnetic resonance imaging (3T MRI) Procedure: diffusion-weighted magnetic resonance imaging Procedure: dynamic contrast-enhanced magnetic resonance imaging Procedure: magnetic resonance spectroscopic imaging Purpose: In standard clinical care, the prostate is imaged by magnetic resonance imaging (MRI) which is a […]

International Ovarian & Testicular Stromal Tumor Registry Condition: Ovarian Stromal Tumor, Testicular Stromal Tumors, Ovarian Small Cell Carcinoma, DICER1 Gene Mutation Purpose: Rare tumors are understudied, yet have the potential to shed light on vast areas of cancer research. Ovarian sex cord-stromal tumors, rare tumors of childhood and young adulthood, have recently been found to […]

Swiss Austrian German Testicular Cancer Cohort Study – SAG TCCS Condition: Testicular Neoplasms Purpose: The majority of testicular cancer patients can be cured with cisplatin-based chemotherapy. Mortality has been reduced even more within the last 15 years due to the stringent application of standard chemotherapy followed by resection of residual disease. This is a positive […]

Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Condition: Childhood Germ Cell Tumor, Ovarian Cancer, Teratoma Intervention: Drug: carboplatin Drug: etoposide Drug: ifosfamide Drug: paclitaxel Drug: thiotepa Procedure: autologous hematopoietic stem cell transplantation Drug: Mesna Biological: filgrastim Purpose: RATIONALE: Germ cell tumors (GCT) are highly sensitive to chemotherapy such that even with metastatic […]