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A Phase 2, Single-Arm Study of Bempegaldesleukin (NKTR-214) in Combination With Nivolumab in Cisplatin Ineligible, Locally Advanced or Metastatic Urothelial Cancer Patients Condition: Urinary Bladder Neoplasm, Neoplasm Metastasis Intervention: Biological: Bempegaldesleukin Biological: Nivolumab Purpose: The main purpose of this study is to evaluate the anti-tumor activity of bempegaldesleukin (NKTR-214) in combination with nivolumab by assessing […]

Treatment of Ta Bladder Cancer in High Risk of Recurrence – Fluorescence Cystoscopy With Optimized Adjuvant Mitomycin-C (FinnBladder 9) Condition: Bladder Cancer Intervention: Procedure: white light TUR-BT Procedure: blue light TUR-BT Drug: optimized MMC Drug: single immediate chemotherapy instillation Purpose: Bladder cancer (BC), the second most common urological malignancy, is an important public health issue. […]

The DUTRENEO Trial: A Prospective Study to Individualize the Approach With DUrvalumab (MEDI4736) and TREmelimumab in NEOadjuvant Bladder Cancer Patients. Condition: Bladder Cancer Intervention: Drug: Durvalumab Drug: Tremelimumab Drug: Cisplatin-based neoadjuvant chemotherapy Purpose: In the treatment of localized/locally advanced urothelial cancer, there are several questions that have not yet been resolved, such as the limited […]

Role of Active Surveillance and Identification of Prognostic Factors for Progression in Early Stage Renal Cell Carcinoma Condition: Patients With Newly Diagnosed Small Renal Masses(<4cm) Purpose: There is a rising incidence of incidentally detected small renal tumours due to improved imaging techniques. Traditionally, patients diagnosed with these small renal masses undergo surgery and therefore there […]

Prospective Randomized Study Comparing Laparoscopic Versus Open Partial Nephrectomy Condition: Kidney Neoplasms Intervention: Procedure: Partial nephrectomy Purpose: Partial nephrectomy is considered the standard treatment for renal tumors smaller than 7 cm. With the evolution of image diagnostic tools and dissemination of its use, smaller tumors are being commonly diagnosed and treated. The partial open nephrectomy […]

Prospective Observational Analysis Of CR With Sunitinib Treatment In mRCC Patients Condition: Complete Remission in Renal Cell Carcinoma Intervention: Drug: sunitinib Drug: sunitinib Purpose: This prospective study will investigate the characteristics of mRCC patients at time of CR in comparison with mRCC patients non on CR treated with Sunitinib, in order to provide some answers/ […]

Is it time to change the way we calculate prostate volume? Several novel imaging methods came on the scene in the last few years (multiparametric MRI, PSMA-PET, among others) to evaluate prostatic diseases. However, we are still taking into account ultrasound measurements to estimate prostate volume. This piece of information is extremely valuable for clinicians […]

Washington, DC (UroToday.com) Now in its 14th year, the Bladder Cancer Advocacy Network’s (BCAN’s) Think Tank continues to be the premier scientific bladder cancer meeting in North America and provides a collaborative setting to identify and overcome obstacles while creating solutions in bladder cancer research and treatment. BCAN’s Think Tank facilitates discussions that help define […]

Radiotherapy is a mainstay of treatment for localized prostate cancer. Biochemical recurrence after radiotherapy, defined as a prostate-specific antigen (PSA) rise of ≥ 2 ng/mL above nadir, occurs in up to 40% of intermediate- and high-risk patients within 10 years of treatment (Eur. Urol. 67, 1009–1016 (2015). Patients with biochemical recurrence are at increased risks of metastases […]