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Magnetic resonance imaging (MRI), with or without MRI-targeted biopsy (MRI pathway), is an alternative test to systematic transrectal ultrasonography-guided biopsy in men suspected of having prostate cancer. At present, evidence on which test to use is insufficient to inform detailed evidence-based decision making. To determine the diagnostic accuracy of the index tests MRI only, MRI-targeted […]

To compare long-term functional outcomes of off-clamp or on-clamp partial nephrectomy patients of two high-volume centers with cT1-2/N0 M0 renal tumors and baseline estimated glomerular filtration rate >60 mL/min. A 3:1 propensity score-matched analysis was used to select two homogeneous cohorts to compare off-clamp versus on-clamp partial nephrectomy. Joinpoint regression analysis was used to compare the […]

Renal cell carcinoma (RCC) has traditionally been regarded as radioresistant tumor based on preclinical data and negative clinical trials using conventional fractionated radiotherapy. However, there is emerging evidence that radiotherapy delivered in few fractions with high single-fraction and total doses may overcome RCC s radioresistance. Stereotactic radiotherapy (SRT) has been successfully used in the treatment […]

9p loss appears a reliable and promising marker able to differentiate specific categories of patients with renal cell carcinoma associated with a worse prognosis. The aim was to systematically evaluate relative risk of death, cancer-specific survival (CSS) and disease-free survival (DFS) among patients harboring 9p loss. We found a total of 92 potentially relevant articles […]

Chicago, IL (UroToday.com)  — Darolutamide, an androgen receptor inhibitor, has received FDA approval for the treatment of patients with nonmetastatic castration resistant prostate cancer (CRPC)1 This priority review is based on the Phase III ARAMIS trial evaluating darolutamide plus androgen deprivation therapy (ADT), which demonstrated a highly significant improvement in the primary efficacy endpoint of metastasis-free survival […]

Kurt Azarbarzin: That there is so many limitations associated with laparoscopy at early stages and even now. And one of those key limitations to me was access and visualization. So we focused on, holistically focused on how do we overcome these limitations. And when I say holistically, we just didn’t go after product, we went […]

Trinity Bivalacqua: Good morning. I’d like to thank Josh and the Engineering Society for giving me a chance to talk today about, number one, a clinical trial that we actually presented last year in the late-breaking abstract, session and also is currently under review. I’m going to ask everyone in this room to keep your […]

National Comprehensive Cancer Network guidelines consider 18F-fluciclovine PET-CT for prostate cancer biochemical recurrence localisation after radical prostatectomy, whereas European Association of Urology guidelines recommend prostate-specific membrane antigen (PSMA) PET-CT. To the best of our knowledge, no prospective head-to-head comparison between these tests has been done so far. The aim of this study was to compare […]