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Prostate cancer (PC) is a multifocal disease. DNA methylation alterations are not restricted to the immediate peritumor environment, but spatially widespread in the adjacent and distant histologically normal prostate tissues. In the current study, we utilized high-throughput methylation arrays to identify epigenetic changes in the urine from men with and without cancer. DNA urine samples […]

The purpose of this study was to examine the influence of transitioning treatment planning techniques in high-dose-rate interstitial brachytherapy monotherapy for localized prostate cancer. We compared 113 patients treated with initial two-dimensional treatment planning (2D: 74% received 54 Gy/nine fractions) to 240 patients treated with three-dimensional planning (3D: 70 CT image-guided 3D [CT-3D]: 84% 45. 5 Gy/seven […]

Multiparametric magnetic resonance imaging (mpMRI) and MRI/ultrasound (US) fusion targeted biopsies are an increasingly popular alternative to randomized biopsies, but adoption of this technique has been limited owing to its additional costs and complexity. High-resolution micro-ultrasound (micro-US) is a real-time US-based imaging modality that allows real-time targeted prostate biopsies using the Prostate Risk Identification Using […]

Circular RNAs (circRNAs) are known to be closely involved in tumorigenesis and cancer progression. Nevertheless, their function and underlying mechanisms in renal cell carcinoma (RCC) remain largely unknown. The aim of this study was to explore their expression, functions, and molecular mechanisms in RCC. We downloaded the circRNA expression profiles from Gene Expression Omnibus (GEO) […]

The molecular mechanism underlying clear cell renal cell carcinoma (ccRCC) metastasis remains unclear. We therefore aimed to elucidate the role of IMPA2 in ccRCC metastatic progression. Using the Cancer Genome Atlas (TCGA) database and immunohistochemistry (IHC) staining, we investigated differences in IMPA2 mRNA and protein expression, as well as their clinical relevance, in ccRCC. To […]

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers […]

There are few effective treatments for patients with advanced clear cell renal cell carcinoma (CCRCC). Recent findings indicate that ruthenium-gold containing compounds exhibit significant antitumor efficacy against CCRCC in vitro affecting cell viability as well as angiogenesis and markers driving those 2 phenomena. However, no in vivo preclinical evaluation of this class of compounds has […]

Diane Newman: Welcome. I’m Diane Newman. I’m a urology nurse practitioner. I specialize in pelvic floor dysfunction, so I see patients with incontinence, overactive bladder, pelvic floor muscle weakness, but I also see a large population of patients who have voiding dysfunction, in the sense that they cannot empty their bladder. They may have urinary […]

Charles Ryan: Hello from ASCO 2019. I’m delighted today to be joined by Wassim Abida, who’s at Memorial Sloan Kettering Cancer Center where he’s a medical oncologist in the genitourinary oncology service. Welcome. Wassim Abida: Thanks. Charles Ryan: You’re doing a lot of great work. Wassim Abida: Thank you. Charles Ryan: And in particular in […]

Phillip Koo: Hello, this is Phillip Koo from UroToday. We’re very fortunate to have with us today, Dr. Frankis Almaguel, who’s Assistant Professor and Director of Molecular Imaging and Therapeutics at the Loma Linda University Cancer Center. He’s here today to continue our lecture series that is sponsored by the Society of Nuclear Medicine and […]