Lymph node metastases at the time of prostatectomy are an infrequent finding. The correlation of the pattern of nodal metastases with patient outcome has yet to be explored. Lymph node positive prostatectomies were retrospectively reviewed. The presence of cribriform carcinoma (CC), intraductal carcinoma (IDC) and ISUP grade (G) were documented. The largest nodal metastasis was […]
Alicia Morgans: Hi. I’m thrilled to have here with me today Dr. Tanya Dorff who is an Associate Professor of Medicine at City of Hope. Thank you so much for being here. Tanya Dorff: Thanks for having me. Alicia Morgans: Of course, I am really enthusiastic about this conversation because you had the great honor […]
Alicia Morgans: Hi, and welcome to ASCO 2019. I’m delighted to have here with me today, Dr. Karim Fizazi, who is a medical oncologist and Professor at Gustave Roussy in Paris. Thank you so much for being here, Karim. Karim Fizazi: Thank you, Alicia, for inviting me today. Alicia Morgans: Of course. So I wanted […]
The typical mean length of stay (LOS) following robotic-assisted laparoscopic prostatectomy (RALP) is 24-48hrs. We began routinely offering same day discharge (SDD) after RALP and evaluate the success rate, safety and cost implications in the only large series of SDD to date.
{{header-clinical-trials-navigation}} A Phase 2, Multicenter, Randomized, Double-Blind, Active-Control Study to Evaluate the Efficacy and Safety of Nivolumab Administered in Combination With IPI-549 Compared to Nivolumab Monotherapy in the Treatment of Patients With Immune Therapy-Naïve, Advanced Urothelial Carcinoma Condition: Bladder Cancer, Urothelial Carcinoma, Solid Tumor, Advanced Cancer Intervention: Drug: IPI-549 Drug: Nivolumab Drug: Placebos Purpose: The […]
It is unknown whether alcohol intake is associated with the risk of lethal (metastatic or fatal) prostate cancer. We examine (1) whether alcohol intake among men at risk of prostate cancer is associated with diagnosis of lethal prostate cancer and (2) whether intake among men with nonmetastatic prostate cancer is associated with metastasis or death. […]
Although radical prostatectomy and external beam radiotherapy are recognized as comparable treatment options for localized prostate cancer, robot-assisted radical prostatectomy (RARP) and volumetric modulated arc therapy (VMAT) as the leading respective techniques have yet to be compared.
Heterogeneity in the genomic landscape of metastatic prostate cancer has become apparent through several comprehensive profiling efforts, but little is known about the impact of this heterogeneity on clinical outcome. Here, we report comprehensive genomic and transcriptomic analysis of 429 patients with metastatic castration-resistant prostate cancer (mCRPC) linked with longitudinal clinical outcomes, integrating findings from […]
The New England journal of medicine. 2019 May 23 [Epub] Santino Butler, Vinayak Muralidhar, Janice Chavez, Zoe Fullerton, Aman Mahal, Michelle Nezolosky, Marie Vastola, Shuang G Zhao, Anthony V D’Amico, Robert T Dess, Felix Y Feng, Martin T King, Kent W Mouw, Daniel E Spratt, Quoc-Dien Trinh, Paul L Nguyen, Timothy R Rebbeck, Brandon A […]
Background: We previously reported the antitumor activity of olaparib (400mg BID) against molecularly unselected mCRPC (TOPARP-A; Mateo et al NEJM 2015). We now report TOPARP-B, a phase II trial for patients with mCRPC preselected for putatively pathogenic DDR alterations. Methods: Patients with mCRPC progressing after ≥ 1 taxane chemotherapy underwent targeted sequencing of tumor biopsies and […]
