ASCO GU 2021: The Oral HIF-2 α Inhibitor MK-6482 in Patients with Advanced Clear Cell Renal Cell Carcinoma (RCC): Updated Follow-up of a Phase I/II Study

(UroToday.com) The treatment landscape for first-line therapy among patients with metastatic renal cell carcinoma (mRCC) has changed dramatically over the past 2 years. In 2018, the publication of the CheckMate214 data demonstrated a survival benefit for patients treated with nivolumab and ipilimumab compared with sunitinib in intermediate and poor-risk mRCC, ushering in the immunotherapy era for […]

ASCO GU 2021: Phase 3 Trial of Lenvatinib plus Pembrolizumab or Everolimus Versus Sunitinib Monotherapy as a First-Line Treatment for Patients with Advanced Renal Cell Carcinoma (CLEAR Study)

(UroToday.com) The treatment landscape for first-line therapy among patients with metastatic renal cell carcinoma (mRCC) has changed dramatically over the past 2 years. In 2018, the publication of the CheckMate214 data demonstrated a survival benefit for patients treated with nivolumab and ipilimumab compared with sunitinib in intermediate and poor-risk mRCC, ushering in the immunotherapy era for […]

ASCO GU 2021: First Results from the Phase 3 CheckMate 274 Trial of Adjuvant Nivolumab vs Placebo in Patients Who Underwent Radical Surgery for High-Risk Muscle-Invasive Urothelial Carcinoma

(UroToday.com) For patients with muscle-invasive bladder cancer who are eligible for curative-intent treatment, cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) is a standard of care with improved pathologic response and overall survival (OS) compared to RC alone. Consolidation with chemoradiotherapy (CRT) is an alternative to RC. However, many patients are cisplatin-ineligible and thus often […]

ASCO GU 2021: Impact of Equal Access Healthcare on Race Disparities in Bladder Cancer

(UroToday.com) In the United States, there are significant racial disparities in cancer outcomes. In prostate cancer, observed differences in survival between black and white men were essentially eliminated in the equal access Veterans Affairs’ (VA) system. As with prostate cancer, outcomes in bladder cancer are disproportionately worse for black patients compared to white patients. In a […]

ASCO GU 2021: Phase II Clinical Study of Concurrent Durvalumab and Radiation Therapy (DUART) Followed by Adjuvant Durvalumab in Patients with Localized Urothelial Cancer of Bladder: Results for Primary Analyses and Survival. BTCRC-GU15-023

(UroToday.com) For patients with muscle-invasive, localized bladder cancer, neoadjuvant chemotherapy followed by radical cystectomy or trimodal therapy are accepted treatment options. Those who are cisplatin-ineligible/unfit for surgery, or have locally advanced and unresectable disease, have limited treatment options. In a plenary abstract presentation in the Rapid Abstract Session: Urothelial Carcinoma and Rare Tumors session at the […]

EAU RF seeding grants: Call for applications

Through a ‘seeding grant’, short-term, exploratory research projects can be supported. The results will determine the potential and long-term feasibility of the research. A seeding grant allows young colleagues with ideas for new research initiatives, which may be high-risk projects, to start working on their research project. Last year, the EAU Research Foundation (EAU RF) […]

X