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(UroToday.com) While cisplatin-based chemotherapy is an accepted first-line treatment for patients with advanced or metastatic urothelial carcinoma and immune checkpoint inhibitors (CPI) are used in both the first-line setting for patients who are cisplatin-ineligible and as maintenance or second-line therapy in those who have previously received cisplatin-based chemotherapy, there are limited treatment options past these. Recently, […]

(UroToday.com) Immune checkpoint blockade using PD-1 and PD-L1 targeting agents has proven clinical benefit in many metastatic carcinomas. However, identification of patients most likely to benefit has been difficult with most predictive biomarkers examined to date (including PD-1/PD-L1 status and tumor mutational burden) failing to demonstrate clinical utility. CDKN2A is one of the most commonly altered genes across […]

(UroToday.com) Platinum-based cytotoxic chemotherapy has been the standard of care for patients with advanced urothelial carcinoma based on improved survival compared to placebo. However, objective response rates are at best 50% and median overall survival is relatively poor at less than 18 months. This has driven the rationale for additional approaches. In first-line (1L) therapy for […]

(UroToday.com) Metastatic castration-resistant prostate cancer (mCRPC) remains a lethal disease despite the increased number of treatment options that have been Federal Drug Administration (FDA) approved in the past decade. Most recently, the PARP inhibitors olaparib and rucaparib were approved for men with mCRPC harboring certain gene alterations associated with homologous recombination deficiency. In this study, […]

(UroToday.com) Conventional imaging modalities including computed tomography and bone scintigraphy are routinely recommended for prostate cancer staging, however, they are limited by relatively low sensitivity and moderate specificity. In contrast, PSMA-based imaging is highly promising for prostate cancer detection, with higher sensitivity, specificity, and accuracy. 18F-DCFPyL is a novel PSMA-targeted radiopharmaceutical for positron emission tomography (PET) […]

(UroToday.com) Advanced urothelial carcinoma has among the worst prognosis for tumors treated by genitourinary oncologists. Standard of care dictates that patients receive platinum-based induction chemotherapy. However, even with this treatment, rates of recurrence and disease progression are high and overall survival is quite short due to the development of chemotherapy resistance. In the JAVELIN Bladder 100 […]

(UroToday.com) The field of advanced prostate cancer has rapidly progressed over the past 15 years. Prior to the publication of TAX-327, there were no proven life-prolonging therapies for patients with metastatic castration-resistant prostate cancer (mCRPC). Since that time, there have been many new agents that have proven survival benefits including taxane-based chemotherapy, agents targeting the androgen […]

(UroToday.com) While the preponderance of patients with bladder tumors have urothelial histology, up to 25% of tumors are of pure variant or mixed urothelial and variant histology. These variant histologies are associated with more advanced stage at presentation and worse response to systemic therapy. In a poster presentation at the 2021 ASCO GU Cancers Symposium, Dr. […]

(UroToday.com) The SPARTAN clinical trial was a randomized phase 3 placebo-controlled patients evaluating the efficacy of the Androgen Receptor antagonist apalutamide in combination with androgen deprivation therapy (ADT) in patients with nonmetastatic castration resistant prostate cancer (nmCRPC) whose PSA doubling time was less than 12 months. The schema of the study is shown below. Patients were […]

(UroToday.com) Metastatic castration resistant prostate cancer (mCRPC) continues to be driven by androgen signaling, but this patient population has heterogeneous responses to second-generation androgen pathway inhibitors. Apalutamide, an androgen receptor antagonist, and abiraterone acetate, and androgen synthesis inhibitor, have somewhat distinct mechanisms of action and efficacy in mCRPC. The ACIS trial (NCT02257736) was designed to study […]