Rethinking Second-Line Therapy for Overactive Bladder to Improve Patient Access to Treatment Options.

Idiopathic overactive bladder (OAB) is a chronic condition that negatively affects quality of life, and oral medications are an important component of the OAB treatment algorithm. Recent literature has shown that anticholinergics, the most commonly prescribed oral medication for the treatment of OAB, are associated with cognitive side effects including dementia.

Considering non-bladder etiologies of overactive bladder: A functional neuroimaging study.

To better understand the neuropathophysiology of overactive bladder (OAB) in women by characterizing supraspinal activity in response to bladder distention and cold stimulation. We recruited 24 female participants, 12 with OAB [median age 40 years (interquartile range 32 – 42)] and 12 healthy controls (HCs) without lower urinary tract (LUT) symptoms [34 years (28 – […]

Temporal Relationships Between Pain, Mood and Urinary Symptoms in Urologic Chronic Pelvic Pain Syndrome (UCPPS): A MAPP Network Study.

To determine the time-lagged, bidirectional relationships among clinical variables of pelvic pain, urinary symptoms, negative mood, non-pelvic pain and quality of life (QOL) in men and women with UCPPS, incorporating interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

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