(1) Background-The five-year overall survival (OS) of muscle-invasive bladder cancer (MIBC) with neoadjuvant chemotherapy and cystectomy is around 50%. There is no validated biomarker to guide the treatment decision.
NCR3LG1 (B7-H6) protein is selectively overexpressed on tumor and is associated with fatal disease progression of various cancer. However, its prognostic value in bladder cancer (BCa) has not been well elaborated.
Bladder cancer continues to afflict more than 80,000 patients in the United States and at least 550,000 persons globally.1,2 Although the scientific community could not meet in person last year due to the COVID-19 pandemic, this did not stop the ongoing exchange of ideas, research, and clinical trials. In this article, I highlight some of […]
MRI-guided high-intensity focused ultrasound effectively treats prostate cancer with minimal side effects. In focal therapy, an ultrasound transducer focuses sound waves to generate heat at a single point within the body and destroy the target tissue. Treatment was successfully completed with no major adverse events, with 41 of 44 participants disease-free at the treatment site […]
It is profound that despite years of intensive therapeutic efforts, a staggering 50-60% of patients with muscle-invasive urothelial bladder cancer will have a local or distant disease recurrence within five years with only limited therapeutic options. Therefore, it is imperative to understand how these tumors develop and continue efforts to identify new therapeutic targets. Because […]
This year, World Cancer Day has launched the third year of its campaign for impact – I Am and I Will, with the theme ‘Together, all our actions matter’.
Prostate cancer among the cancers considered for possible extension of targeted cancer screening We warmly welcome the launch of Europe’s Beating Cancer Plan of the European Commission, in particular the planned activities under early detection. The Commission aims to propose an update on the European Council’s Recommendation on cancer screening by 2022, including the potential […]
Background To reduce adverse effects of whole-gland therapy, participants with localized clinically significant prostate cancer can undergo MRI-guided focal therapy. Purpose To explore safety and early oncologic and functional outcomes of targeted focal high-intensity focused ultrasound performed under MRI-guided focused ultrasound for intermediate-risk clinically significant prostate cancer.
Management of patients with atypical urinary cytology (class III) of the upper urinary tract is often complicated because some patients develop upper urinary tract urothelial carcinoma (UTUC). Here, we aimed to help define the optimal management of these patients.
Testicular cancer (TC) is the most frequent solid tumor diagnosed in young adult males. Although it is a curable tumor, it is frequently associated with considerable short-term and long-term morbidity.
