Infertility is a significant global health problem that currently affects one of six couples in reproductive age. The quality of male reproductive cells dramatically decreased over the last years and almost every aspect of modern life additionally worsen sperm functional parameters that consequently markedly increase male infertility. This clearly points out the importance of finding a new approach to treat male infertility. Redox signaling mediated by reactive oxygen, nitrogen and sulfur species (ROS, RNS, and RSS respectively), has appeared important for sperm reproductive function. Present review summarizes the current knowledge of ROS, RNS, and RSS in male reproductive biology and identifies potential targets for development of novel pharmacological and therapeutic approaches for male infertility by targeted therapeutic modulation of redox signaling.

BioFactors (Oxford, England). 2019 Jun 11 [Epub ahead of print]

Vesna Otasevic, Ana Stancic, Aleksandra Korac, Aleksandra Jankovic, Bato Korac

University of Belgrade, Institute for Biological Research “Sinisa Stankovic”, Belgrade, Serbia., University of Belgrade, Faculty of Biology, Center for Electron Microscopy, Belgrade, Serbia.