Treatment of overactive bladder (OAB) with antimuscarinic agents has been shown to improve depression and/or anxiety symptoms.

The aim of this study was to evaluate the efficacy of mirabegron on OAB symptoms and its effects on depression and/or anxiety of treatment-naïve women with OAB.

Women treated with mirabegron were prospectively evaluated by the OAB symptom score and hospital anxiety and depression Scale before and at 4 and 8 weeks after treatment. Wilcoxon signed-rank and Spearman rank correlation coefficient were used for statistical analyses, and a p value of < 0.05 was considered as significant.

Of the 112 patients who were enrolled, 25.0% had been previously diagnosed as having clinical anxiety and 22.3% as having clinical depression. The OAB, anxiety, and depression symptom scores were significantly improved at both 4 and 8 weeks (p < 0.05). Anxiety, but not depression, symptoms were significantly correlated with OAB symptoms.

Improvement of OAB symptoms helps relieve anxiety, but not depression.

Urologia internationalis. 2019 Feb 21 [Epub]

Manami Kinjo, Tsuyoshi Yamaguchi, Mitsuhiro Tambo, Takatsugu Okegawa, Hiroshi Fukuhara

Department of Urology, Kyorin University School of Medicine, Tokyo, Japan, ., Department of Urology, Kyorin University School of Medicine, Tokyo, Japan.